Algorithm Research & Explore
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App. Res. of Comp. Printed Article
Vol. 38, 2021 No. 8
2365-2369

Classification method of digital PCR droplets based on grid regional DBSCAN clustering

Rong Zhangquan1
Liao Limin2
Zhang Duanjin1
1. School of Information Engineering, Zhengzhou University, Zhengzhou 450001, China
2. Guangdong Shunde Innovative Design Institute, Foshan Guangdong 528311, China
DOI: 10.19734/j.issn.1001-3695.2020.11.0371

Abstract

The software of digital PCR system lacked the function for classifying droplets of multiplex experiments. This paper proposed a grid regional DBSCAN clustering algorithm. Firstly, it mapped data to the gridded space and established gridded indexes; then it calculated weights of grids and performing deep search expansion; finally, it mapped the clustering results in gridded space back to the data space. Tests on artificial datasets show that the proposed algorithm is able to identify the sample points in edge area and of high efficiency. On this basis, it proposed a classification method of digital PCR droplets based on grid regional DBSCAN clustering. It used both the proposed method and existing methods to classify digital PCR droplets. The results show that this method is a convenient and accurate method for classification of digital PCR droplets. Therefore, the proposed method is suitable for classification of digital PCR droplets.

Foundation Support

国家教育部产学合作协同育人项目(201801158025)

Publish Information

DOI: 10.19734/j.issn.1001-3695.2020.11.0371
Publish at: Application Research of Computers Printed Article, Vol. 38, 2021 No. 8
Section: Algorithm Research & Explore
Pages: 2365-2369
Serial Number: 1001-3695(2021)08-021-2365-05

Publish History

[2021-08-05] Printed Article

Cite This Article

荣章权, 廖丽敏, 张端金. 基于网格区域化DBSCAN聚类的数字PCR液滴分类方法 [J]. 计算机应用研究, 2021, 38 (8): 2365-2369. (Rong Zhangquan, Liao Limin, Zhang Duanjin. Classification method of digital PCR droplets based on grid regional DBSCAN clustering [J]. Application Research of Computers, 2021, 38 (8): 2365-2369. )

About the Journal

  • Application Research of Computers Monthly Journal
  • Journal ID ISSN 1001-3695
    CN  51-1196/TP

Application Research of Computers, founded in 1984, is an academic journal of computing technology sponsored by Sichuan Institute of Computer Sciences under the Science and Technology Department of Sichuan Province.

Aiming at the urgently needed cutting-edge technology in this discipline, Application Research of Computers reflects the mainstream technology, hot technology and the latest development trend of computer application research at home and abroad in a timely manner. The main contents of the journal include high-level academic papers in this discipline, the latest scientific research results and major application results. The contents of the columns involve new theories of computer discipline, basic computer theory, algorithm theory research, algorithm design and analysis, blockchain technology, system software and software engineering technology, pattern recognition and artificial intelligence, architecture, advanced computing, parallel processing, database technology, computer network and communication technology, information security technology, computer image graphics and its latest hot application technology.

Application Research of Computers has many high-level readers and authors, and its readers are mainly senior and middle-level researchers and engineers engaged in the field of computer science, as well as teachers and students majoring in computer science and related majors in colleges and universities. Over the years, the total citation frequency and Web download rate of Application Research of Computers have been ranked among the top of similar academic journals in this discipline, and the academic papers published are highly popular among the readers for their novelty, academics, foresight, orientation and practicality.

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